Here's an idea for a TV show - take the format of the show Friends (including opening song and everything) but instead of the cast of Friends you'd have a real-life grown up versions of Charles Shulz' Peanuts characters.
Instead of a coffee shop - most of the action would take place at a piano bar with Schroeder being the "piano man". Lucy van Pelt, despite having a Ph. D in psychology, is the hostess at the piano bar restaurant (just to be close to Schroeder). Each week Lucy could give an psychoanalysis of whatever issue one of the gang is dealing with. Sort of a running gag. Schroeder could insist everyone call him "maestro" as a Seinfeld shout-out.
Charlie Brown's sister Sally could be played by a blonde hottie and the character would be sort of a slut. His best friend, Linus van Pelt could be played by one of The Big Bang actors who could geek slap big sister Lucy any time one of her on the spot psychoanalytical diagnosis makes no logical sense.
Peppermint Pattie and Marcie would, of course, be lesbians. Maybe Sue Lynch for Pattie and KD Lang for Marcie? Pig Pen could be a recovering drug addict. How could this not work?
And for Charlie Brown - I picture a younger version of Paul Giamatti. I would seriously watch this show if it were ever made.
EDIT: Literally less than an hour after writing the above I saw this Charlie Brown as Louie video. Too funny!